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filingDate 2001-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2003-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2003534808-A
titleOfInvention Method for preparing R- or S-form α-substituted heterocyclic carboxylic acid and enantiomer α-substituted heterocyclic carboxylate using an enzyme
abstract (57) [Summary]nAn object of the present invention is to provide a method for preparing an R- or S-form α-substituted heterocyclic carboxylic acid and an enantiomer α-substituted heterocyclic carboxylate having an opposite mirror image using an enzyme.nDisclosed is a method for producing an R- or S-form α-substituted heterocyclic carboxylic acid (α-HCCA) and its opposite enantiomer α-HCCA ester using an enzyme. Racemic α-HCCA is reacted with an alcohol to produce a racemic α-HCCA ester, which is contacted with an enzyme having enantioselectivity to hydrolyze the R-form or S-form racemate . This can be extracted with an organic solvent to obtain the enantiomer α-HCCA ester. Therefore, α-ACCA of the specific enantiomer having high optical purity and α-HCCA ester of the opposite enantiomer can be produced in high yield and at low cost.
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