| abstract |
(57) [Summary]nThe present invention provides full-length cDNA sequences encoding G protein-coupled receptors, as well as complete genes and encoded proteins. The present invention provides recombinant cell lines that express these receptors at appropriate levels so that novel compounds having activity at these receptors can be identified for therapeutic use. The receptor sequences described in the present invention are members of a novel GPCR receptor subfamily without known endogenous ligands. This cDNA can be used to identify new compounds with activity at the receptor, especially for therapeutic intervention in the field of CNS disorders, more specifically for the treatment of bipolar affective disorder (BPAD). The nucleotide sequence of this gene can be used for diagnostic purposes in psychiatric patients and susceptible populations. |