abstract |
(57) [Summary]nIn the present invention, Y is hydrogen, halogen, alkyl (1-3C) or CN, CF Three , OCF Three , SCF Three , Alkoxy (1-3C), amino, or mono- or dialkyl (1-3C) -substituted amino, or hydroxy, and X is O, S, SO or SO Two Z represents -C, = C or -N; 1 And R Two Independently represents hydrogen or alkyl (1-3C); Q is benzyl or 2-, 3- or 4-pyridylmethyl; -3C) alkylamino, (1-3C) alkoxy, CF Three , OCF Three , SCF Three , A group of novel piperazine and piperidine derivatives of the formula which may be substituted with one or more substituents from (1-4C) -alkyl, (1-3C) alkylsulfonyl or hydroxy, and salts and Regarding prodrugs. These compounds are dopamine D Two -It has been found to have interesting pharmacological properties due to a combination of (partial) agonism on members of the receptor subfamily and affinity for the related serotonin and / or noradrenergic receptors.nEmbedded image |