abstract |
(57) Summary (I) wherein X is oxygen or sulfonyl, R is a ring, R 1 is cycloalkyl, y and z are 0 or 1, and R 2 is — Compounds that are CO-NHR 3 or heteroaromatic rings with a ring nitrogen atom adjacent to the linking ring carbon atom) are active as glucokinase activators that increase insulin secretion, and thus treat type II diabetes Has become useful. |