| abstract |
(57) Abstract: The present invention, in novel substituted diamine derivatives (of formula (I), R? 1, R 2, R 3, R 4, X 1, X 2, X 3, X 4, A , Y and n are as described in the specification), and pharmaceutical compositions containing them, and intermediates used in their manufacture. More particularly, the compounds of the invention are motilin receptor antagonists useful in the treatment of related conditions and disorders such as gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel syndrome. |