| abstract |
(57) [Summary]nThe present invention relates to a hemostatic, comprising a macromolecular intermolecular complex of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, and optionally comprising a polyvalent cation and / or a polycation and / or a hemostatic agent. The present invention relates to improved methods of making and using bioadhesive, bioresorbable, anti-adhesion compositions. The polymers are associated with one another and dried to a membrane or sponge, or used as a fluid, gel, or foam. The hemostatic, bioresorbable, bioadhesive, anti-adhesion compositions are useful for preventing surgical bleeding and the formation and reformation of post-surgical adhesions. The composition is designed to be degraded in vivo and thus removed from the body. The hemostatic, anti-adhesion, bioadhesive, bioresorbable, anti-thrombogenic and / or physical properties of the composition include pH, solids cation content of polymer casting solution, polyacid composition, polyalkylene oxide composition Can be varied by careful adjustment or by adding a hemostat. Hemostatic membranes, gels and / or foams can be used simultaneously. The hemostatic, anti-adhesion composition may also be used to lubricate tissue and / or medical devices and / or deliver the drug to the surgical site to release the drug locally. |