abstract |
(57) [Summary] The present invention relates to a reovirus that selectively lyses ras-mediated neoplastic cells, and from a mixed cellular composition to a ras-mediated neoplasm by infecting the mixed cellular composition. A method for removing cells. Because many neoplastic cells are associated with the activated ras pathway, the present invention can be used to remove mixed or spontaneous neoplastic cells from a wide variety of mixed cellular compositions. |