| abstract |
(57) [Summary]nThe present invention provides pharmaceutical compounds useful in treating type II diabetes. These compounds are advantageous because they are readily metabolized by metabolic drug detoxification systems. In particular, provided are thiazolidinedione analogs designed to include an ester within the structure of the compound. The present invention also includes a method of treating a disorder such as diabetes, comprising administering a therapeutically effective composition comprising a compound designed to be metabolized by serum or intracellular hydrolases and esterases. Also about the method. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught. |