abstract |
(57) [Summary]nA heating method for preparing an effervescent granule formulation containing a pharmacologically active agent, which can form an acidic agent, an alkaline agent, a complete or partial eutectic with said acidic agent Incorporating a hot melt extrudable binder, a pharmacologically active agent and optionally a plasticizer, the acidic agent, the alkaline agent, the hot melt extrudable binder and optionally a plasticizer. A method comprising dry blending to form a first mixture and extruding said mixture with a hot melt to form said expandable granules having a controllable expansion rate. The above-mentioned pharmacologically active drugs include synthetic antidiarrheal drugs, anxiolytics, diuretics, serotonin agonists, levorotatory isomers of thyroxine, cholesterol-lowering drugs, α-adrenergic drugs Sex blockers, antiviral agents, anesthetics, or an antidepressant. |