http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003530575-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2001-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003530575-A |
| titleOfInvention | Specific inhibitors of ribosome recycling factor (RRF) |
| abstract | (57) [Summary]nSOLUTION: Oligoguanylic acid inhibits the activity of ribosome recycling factor (RRF), a soluble factor responsible for the degradation of "post-arrest complex". RRF is essential in all bacteria because it is necessary for recycling of the used ribosomes to initiate translation of other mRNAs into other polypeptides. Since eukaryotic cytoplasmic protein synthesis does not require RRF, inhibitors of REF are effective as antibacterial agents. The present invention provides oligoguanylic acid, sd-G4 or a derivative thereof, which can be used as a lead compound for the development of a new antibacterial therapeutic agent. |
| priorityDate | 2000-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 254.