http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003529528-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-00 |
| filingDate | 1999-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003529528-A |
| titleOfInvention | Amino acid amidinohydrazones, alkoxyguanidines, and aminoguanidines as protease inhibitors |
| abstract | (57) Abstract: The present invention relates to a compound of the formula (I) wherein X is O or NR 19 , A 1 , A 2 , R 7 to R 10 , R 18 , R a , R b , R c , n and m relate to aminoguanidine and alkoxyguanidine compounds, including those described herein), and hydrates, solvates, or pharmaceutically acceptable salts thereof, such as thrombin Inhibits proteolytic enzymes. Methods for preparing compounds of formula (I) are also described. Certain compounds exhibit antithrombotic activity via direct and selective inhibition of thrombin or are useful intermediates for forming compounds having antithrombotic activity. The present invention provides a composition for inhibiting platelet loss, inhibiting platelet aggregate formation, inhibiting fibrin formation, inhibiting thrombus formation, and inhibiting emboli formation in a mammal. Include. Other uses of the compounds of the invention are either included in, or physically linked to, materials used in the manufacture of devices used for blood collection, blood circulation, and blood storage. As an anticoagulant. |
| priorityDate | 1998-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 371.