| abstract |
(57) [Summary]nThe present invention relates to a compound of formula (I):n[Chemical 1]n Wherein Z is oxygen or sulfur; R 1 Is hydrogen, -CHN 2 , -R, -CH 2 OR, -CH 2 SR or -CH 2 Y; Y is an electronegative leaving group; R 2 Is CO 2 H, CH 2 CO 2 H, or an ester, amide or isostere thereof; R 3 Is a group compatible with the S2 subsite of the caspase enzyme; R 4 And R 5 Together with the intervening nitrogen form a heterocycle and R is as described herein. This compound is an effective inhibitor of apoptosis and IL-1β secretion. |