| abstract |
(57) Disclosed are compounds of formula (I); or pharmaceutically acceptable non-toxic salts thereof, wherein A is N or CH; and R 1 and R 2 are hydrogen or lower alkyl. G, R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are variables as defined herein. These compounds are modulators of the CRF receptor and are therefore useful in treating affective disorders, anxiety, depression, eating disorders, and stress disorders in humans and other animals. In addition to methods of treating such disorders, packaged pharmaceutical compositions are also provided. The compounds of the present invention are also useful as probes for CRF receptor localization and as standards in assays for CFR receptor binding. Methods of using these compounds in receptor localization studies are provided. Embedded image |