| abstract |
(57) [Summary] The present invention has the following structure: [Wherein n is 1-5, X is N or CR 5 (where R 5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl), Z is a heteroaryl group, and R 1 , R 2 , R 3 and R 4 are as defined herein, and when X is N, it is preferred that R 1 is aryl or heteroaryl], antianginal and cardioprotective agents As a sodium / proton exchange (NHE) inhibitor, and a method for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis and arrhythmia using the heterocyclic derivative To do. |