| abstract |
(57) Abstract: The present invention relates to prostate cancer cells, prostate stromal cells, perivascular cells, proliferative cancer-related osteoblasts and prostate cancer and related bone stromal cells that do not express PSA or androgen receptor (AR). The present invention relates to a replicable adenovirus vector specific to a cell, such as a cell, in which an osteocalcin transcription regulatory sequence functions, and a method for using such a virus is provided. These viruses contain an adenovirus gene under the control of osteocalcin transcriptional regulatory sequences. The gene can be, for example, a gene required for adenovirus replication. These viruses can also include at least one additional adenovirus gene under the control of at least one additional tissue-specific transcriptional regulatory sequence. As a result, viral replication can be restricted to target cells that exhibit osteocalcin gene expression. Such replicable adenovirus vectors are useful for treating prostate, brain, ovarian, thyroid, various tumors, osteosarcoma, ocular melanoma, lung or breast cancer. |