http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003525883-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6081 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2001-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003525883-A |
| titleOfInvention | vaccine |
| abstract | (57) [Summary]nThe present invention relates to novel vaccine therapies and prophylactic treatment of atherosclerosis. Thus, an immunogen comprising an apolipoprotein or a fragment or derivative thereof is provided, and the complete apolipoprotein, in its native form, has the following activities: (a) inhibiting the binding of apolipoprotein B to its receptor, and / or Or (b) inhibition of lipoprotein lipase. One preferred example of such an apolipoprotein is apolipoprotein C-III (ApoCIII). Vaccines of the invention comprising the immunogen are effective in preventing or reducing the formation of atherosclerotic plaque over a long period of time, thereby reducing the likelihood of atherosclerosis causing coronary or cerebrovascular disease . Accordingly, there is provided a novel method of treating atherosclerosis by selectively inhibiting the activity of a particular apolipoprotein in a human host, wherein the apolipoprotein in a preferred embodiment of the present invention is ApoCIII, wherein the human comprises Administering an agent that results in the selective inhibition of activity. Also, apolipoproteins having at least one of the following activities by active vaccination or: (a) inhibiting the binding of apolipoprotein B to its receptor, and / or (b) inhibiting lipoprotein lipase. Passive vaccination by administering to a patient an antibody capable of binding to a protein provides a method of treating or preventing atherosclerosis, wherein the antibody in this aspect of the invention binds to ApoCII and It is preferred to exclude activity. Furthermore, there is provided the use of the immunogen or vaccine of the present invention as a medicament, and a method for preparing the same. |
| priorityDate | 2000-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 198.