| abstract |
(57) [Summary] The present invention relates to a chroman compound having the structure of formula (1) for the manufacture of a medicament for use in therapy involving an estrogen receptor, wherein R 1 is (1C-4C) alkyl. , (2C-4C) alkenyl or (2C-4C) alkynyl, independently, R 1 is in cis configuration relative to the exocyclic phenyl group at the 2-position of the carbon skeleton; R 4 is halo, CF 3 , OH or (1C-2C) alkyloxy; R 2 , R 3 , and R 5 are independently hydrogen, halo, CF 3 , (1C-4C) alkyl, (2C-4C) alkenyl, Or (2C-4C) alkynyl) and their prodrugs. [Chemical 1] |