| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23C2230-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8121
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L1-305
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2001-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2003-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2003521914-A |
| titleOfInvention |
C1 inhibitors produced in milk of transgenic mammals |
| abstract |
(57) Abstract The present invention provides a transgenic non-human mammal that expresses a C1 inhibitor in its milk. C1 inhibitors are useful for treating patients with hereditary angioedema or in need of immunosuppression. In one aspect of the present study, the non-human mammal is a DNA segment that encodes a C1 inhibitor that is heterologous to the mammal and that promotes expression of the DNA segment in mammary cells of the mammal. A DNA segment operably linked to at least one effective regulatory sequence, and a segment encoding a signal peptide functional in breast cells of the mammal; wherein the C1 inhibitor encodes A DNA segment is provided in a mammary gland of an adult form of the mammal or a female progeny thereof to provide a non-human mammal capable of producing a C1 inhibitor in the milk of the non-human mammal. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10690670-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011526495-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9738694-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009520815-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016511394-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11754570-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012050465-A |
| priorityDate |
2000-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |