| abstract |
(57) [Summary]nThe present invention relates to novel inhibitors of the enzyme DPP-IV, which are therapeutically active and selective. A novel 2-substituted unsaturated heterocyclic compound in which a nitrogen atom in a heterocycle is bonded to an amino acid or an amino acid derivative via an amide bond or a peptide bond is provided. These compounds are potent and selective inhibitors of DPP-IV and are effective in therapeutic conditions that are suppressed or normalized through inhibition of DPP-IV. |