| abstract |
(57) [Summary]nThe present invention is useful for the dual targeting of viruses (ie, targeting the virus for more than one step in the virus life cycle) and thereby treating viral infection in mammals by inhibiting virus replication. Compositions and methods. The compositions of the present invention include compounds comprising a phosphocholine moiety covalently linked to a lipid backbone with one or more antiviral agents (eg, nucleoside analogs, protease inhibitors, etc.). The invention also includes pharmaceutical compositions and kits for use in treating a viral infection in a mammal. The method of the invention comprises administering to a mammal infected with the virus an effective amount of a compound of the invention, a pharmaceutically acceptable salt thereof, or a composition of the invention, for treating the infection. It becomes. Further, the invention includes compositions and methods useful for controlling cancer in a mammal and facilitating delivery of a therapeutic agent to mammalian cells. The compositions of the present invention comprise a compound comprising an alkyl lipid or phospholipid moiety covalently linked to an anti-cancer agent (eg, a nucleoside analog). The invention also includes pharmaceutical compositions and kits for controlling cancer and facilitating delivery of a therapeutic agent to mammalian cells. The method of the present invention provides an effective amount of a compound of the present invention, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of the present invention for controlling cancer and facilitating delivery of a therapeutic agent to mammalian cells. Administering an article. |