| abstract |
(57) [Summary]nThe following features: (a) The gene in the genome is inactivated and / or the components of the signal transduction pathway are modified by the sequence in which the AP-1 activity is modified, wherein the gene is a transcription factor (B) the fibroblast of the present invention, wherein the active subunit is expressed only after the induction of the promoter, or Contains the gene of (a) operably linked to a promoter in an expression vector, wherein the subunit encoded by is present in an inactive form but can be activated. Disclosed fibroblasts. The invention also relates to identifying compounds that can promote, inhibit or modify the AP-1 dependent differentiation and / or proliferation of keratinocytes, or involve in AP-1 dependent differentiation and / or proliferation of keratinocytes. The present invention relates to a method of using the fibroblast of the present invention for identifying a gene. The present invention further relates to the use of a test compound or gene identified by the method of the present invention for the treatment or diagnosis of a disease associated with a disorder of keratinocyte proliferation and / or differentiation. |