abstract |
(57) [Summary]nThe TCL1 gene family located at the 14q32.1 locus on the human chromosome is thought to be involved in T cell malignancies. The present invention discloses the identification and identification of a new member of this gene family, the TCL-1b gene. The TCL-1b gene sequence is expressed at very low levels in normal bone marrow and peripheral lymphocytes, but is activated in T-cell leukemia and lymphoma by recombination of the 14q32.1 locus. The present invention relates to the identification of these chromosome 14 abnormalities, and methods for detecting and treating any T-cell malignancies that arise, and the prevention of the development of these T-cell malignancies. |