| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-126 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-11013
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 |
| filingDate |
2001-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2003-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2003518952-A |
| titleOfInvention |
EGS molecule that specifically down-regulates expression of bcl-xL |
| abstract |
(57) [Summary]nThe present invention provides a nuclease-resistant external guide sequence (EGS) oligonucleotide whose sequence is selected from the group consisting of Inno-1405, Inno-1407, and Bcl-xL1 listed in Table 1. The present invention also provides a method for inducing cleavage of a specific intracellular mRNA through activation of RNace P, which comprises contacting a cell with a mixture containing an EGS oligonucleotide and a carrier. The present invention provides a method of down-regulating PKC-α protein expression and PKC-α mRNA expression, comprising contacting a cell with a mixture comprising an EGS oligonucleotide and a carrier. The present invention provides a method of down-regulating bcl-xL protein expression and bcl-xL mRNA expression, comprising contacting a cell with a mixture comprising an EGS oligonucleotide and a carrier. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007535579-A |
| priorityDate |
2000-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |