| abstract |
(57) SUMMARY Generally, immune response cDNAs TZap7 / A, TZap7 / B and TZap7 polynucleotides encoding novel proteins involved in immune response regulation, and antibodies recognizing these proteins are described. In addition, vectors comprising said polynucleotides and host cells transformed with said vectors and their use in the production of said proteins are described. Further, a pharmaceutical composition and a diagnostic composition comprising any one of the polynucleotide, vector, protein or antibody described above are provided. Further, methods and uses for modulating an immune response with a novel TZap protein, and pharmaceutical compositions comprising an agent that acts on the TZap protein or its ligand are described. Also, for use in organ transplantation, for the preparation of a diagnostic composition and a pharmaceutical composition for treating an autoimmune disease, an allergic disease, or an infectious disease, or for treating a tumor, Uses for polynucleotides, vectors, proteins, or antibodies are provided. |