abstract |
(57) [Summary]nSubstituted 1,3,4-oxadiazole compounds decrease the level of TNFα in mammals. As a specific embodiment, 2- [1- (3-cyclopentyloxy-4-methoxyphenyl) -2- (1,3,4-oxadiazol-2-yl) ethyl] -5-methylisoindoline -1,3-dione and 2- [1- (3-ethoxy-4-methoxyphenyl) -2- (1,3,4-oxadiazol-2-yl) ethyl] isoindoline-1,3-dione There is. |