| abstract |
(57) [Summary]nThe present invention provides a compound of the structure (I):nEmbedded imagen [Wherein X is -CH 2 -Or a bond; Y is-(CH 2 ) m -Or- (CH 2 ) -O- (CH 2 M is 0 or 1; n is 0 or 1; R 1 And R 2 Is independently selected from optionally substituted aryl or heteroaryl], optical isomers and pharmaceutically acceptable salts thereof, and the use thereof to provide neuroprotection; Neurodegenerative processes in mammals (e.g., Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS dementia, retinal disease, diabetic peripheral neuropathy, multiple sclerosis, stroke, acute thromboembolic cerebral infarction, focal ischemia, Methods for preventing or limiting global cerebral ischemia, transient cerebral ischemic attacks, ischemia resulting from surgery, head trauma, spinal cord trauma, hypoxia, fetal hypoxia) and neuroprotection are provided. |