http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003516976-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-20 |
| filingDate | 2000-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003516976-A |
| titleOfInvention | Novel 3-oxo-2,1-benzisoxazole-1 (3H) -carboxamide for the treatment of CNS disease |
| abstract | (57) [Summary]nThe present invention provides a compound represented by the formula (I) 1 And R Two Are the same or different and independently of one another, hydrogen, halogen, (C 1 ~ C 6 ) -Alkyl, (C 1 ~ C 6 ) -Alkoxy, (C 1 ~ C Three ) -Perfluoroalkyl, (C 1 ~ C Three ) -Perfluoroalkoxy or group -NR Five R 6 R; Three And R Four Are the same or different and independently of one another, (C 1 ~ C 8 ) -Alkyl whose carbon chain optionally has an oxygen or sulfur atom or a group NR 7 May be intervened and optionally (C Three ~ C 6 ) -Cycloalkyl, (C 1 ~ C Four ) -Alkoxy, hydroxyl, halogen or NR 8 R 9 Mono- or polysubstituted by a group selected from the group consisting of (C 1 ~ C 8 ) -Alkyl; (C Three ~ C 8 ) -Cyclalkyl whose carbon chain optionally has an oxygen or sulfur atom or a group NR Ten May be intervened, and optionally (C 1 ~ C Four ) -Alkoxy, hydroxyl, halogen or NR 11 R 12 Mono- or polysubstituted by a group selected from the group consisting of (C Three ~ C 8 ) -Cycloalkyl; Three And R Four Together with a nitrogen atom forms a saturated or partially unsaturated 3- to 10-membered monocyclic or bicyclic heterocyclic ring, which heterocyclic ring is optionally selected from the group consisting of nitrogen, oxygen and sulfur. Up to additional heteroatoms and may optionally contain (C 1 ~ C Four ) -Alkyl, (C 1 ~ C Four ) -Alkoxy, hydroxyl, halogen, COOR 13 Or NR 14 R Fifteen A new 3-oxo-2,1-benzoisoxazole-1 (3H) -carboxamide (I), which may be substituted by a group selected from the group consisting of and X represents oxygen or sulfur. The invention further relates to a process for their preparation and to a medicament for the prevention and / or treatment of diseases of the central nervous system, in particular cognitive diseases such as Alzheimer's disease and other forms of dementia, cerebral infarction, skull and brain injury and pain. Their use in the manufacture of |
| priorityDate | 1999-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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