| abstract |
(57) Summary The present invention is a route to a stereospecific 3-substituted 5-membered ring isomer of formula (A). The end products are epilepsy, stunning seizures, hypokinetic disease, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation Particularly useful as an agent in the treatment of arthritis, dyssomnia, premenstrual syndrome and hot flashes. The present invention provides a compound of formula R is C 1 -C 1 0 alkyl or C 3 -C 10 cycloalkyl (I), similar (II), gabapentin (III) and (IV) (Neurontin (R)) Provides a novel route for the stereoselective synthesis of the body and its pharmaceutically acceptable salts. [Chemical 1] |