http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003514828-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4713 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2000-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003514828-A |
| titleOfInvention | Methods and compositions for preparing peptide constructs useful for treating host versus graft conditions associated with autoimmunity and transplanted tissue |
| abstract | (57) [Summary]nA first peptide segment comprising an amino acid sequence associated with an autoimmune disease, asthma, allergy or xeno- and allograft rejection binds to T cells and elicits an immune response from a deleterious Th1 response to a less harmful Th2 response. Redirected or contained directly bound via a linker or spacer to a second peptide that binds to the T cells but initiates an incomplete but immune response and causes the T cells bound to the first peptide to undergo anergy and apoptosis The resulting peptide constructs are useful for treating autoimmune conditions. For example, the peptide construct NGQEEKAGVVSTGLIGGGDSAFDVLSFTAEEKAGVYK (SEQ ID NO: 14), where the Th2 stimulating peptide G (SEQ ID NO: 15) is covalently linked to the cardiac myosin molecule My1 (SEQ ID NO: 16) via a spacer GGG, is used to treat myocarditis. Or can be used for prevention. |
| priorityDate | 1999-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 378.