| abstract |
(57) SUMMARY The present invention provides NB-ARC and CARD containing proteins (NACs), nucleic acid molecules encoding NACs, and antibodies specific for at least one NAC. The present invention further provides chimeric NAC proteins. The invention also provides screening assays for the identification of agents that can effectively alter NAC association with NAC-related proteins. The invention further provides a method of modulating apoptosis in a cell by introducing a nucleic acid molecule encoding NAC or an antisense nucleotide sequence into the cell. The invention also provides a method of diagnosing a pathology characterized by increased or decreased levels of apoptosis in cells using a reagent capable of binding specifically to US0024125. |