| abstract |
(57) Abstract: The present invention relates to a group of indolylquinone compounds that inhibit the function of GRB-2 adapter protein, pharmaceutical compositions containing these compounds, and the use of these compounds for GRB-2 adapter protein function. A method for alleviating the symptoms of a cell proliferative disorder. The present invention also provides methods of treating insulin-related disorders, such as diabetes, insulin resistance, insulin deficiency and insulin allergy, and reducing the symptoms of insulin-related disorders using certain indolylquinone compounds and pharmaceutical compositions thereof. About the method. The present invention also relates to novel synthetic methods for producing mono- and bis-indolylquinone compounds. |