| abstract |
(57) Abstract: Compounds Useful thieno benzisoxazolyl as D 4 antagonists - a class of phenoxy-substituted propyl derivatives - and thienyl pyrazolyl. The compounds are useful for the treatment of medical conditions mediated by inhibition of D 4 receptor. These symptoms include, for example, attention deficit hyperactivity disorder, obsessive impulsive obsessive-compulsive disorder, mental illness, substance abuse, drug addiction, Parkinson's disease, tremor paralysis, delayed abnormal movements, Jill de la Tuo Rett syndrome, behavioral disorders and rebellious challenging disorders are included. Another aspect of the present invention provides pharmaceutical compositions, intermediates, and methods for preparing the above classes of compounds. |