| abstract |
(57) Abstract: Compounds of formula (Ia), (Ib), (Ic), (Id), wherein w is NH, S, SO or SO 2 ; R 2 is (un) Substituted aryl, (un) substituted heteroaryl or (un) substituted carbocyclic or heterocyclic; Q is hydrogen or lower alkyl; R 4 and R 6 are the same or different and are hydrogen, halogen, lower alkyl R 8 is hydrogen, lower alkyl, or a 3-7 membered (un) substituted aryl, (un) substituted aryl, (un) substituted heteroaryl, (un) substituted arylalkyl or (un) substituted heteroarylalkyl; Or R 8 is a (un) substituted aryl, (un) substituted heteroaryl, or a substituted carbocyclic group wherein up to two of the ring members are heteroatoms optionally selected from oxygen and nitrogen; (Not) replacement Discloses Ruarukiru or (un) the compound is a substituted heteroarylalkyl. These compounds are useful in treating cell proliferative disorders such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases. The present invention also provides a method for treating a cell proliferative disorder. The present invention further provides a pharmaceutically acceptable composition containing the compound of formula (I). Embedded image |