| abstract |
(57) [Summary]nA method for the prevention and therapeutic treatment of a bacterial infection, comprising an effective amount of a modified lytic enzyme produced by a bacterium infected with a bacteriophage specific to the bacterium, and for delivering the lytic enzyme Treating the individual with a carrier, wherein the at least one modified lytic enzyme is selected from the group consisting of a shuffled lytic enzyme and a chimeric lytic enzyme, wherein the lytic enzyme activates the lytic enzyme. Disclosed is a method that exists in an environment having: Further, a holin enzyme for making a hole in the membrane may be included in the composition. The methods and compositions of the present invention can be used for the treatment of upper respiratory tract infections, skin infections, wounds and burns, vaginal infections, eye infections, bowel diseases and dental problems. |