| abstract |
(57) Abstract: An optionally substituted cycloalkyl, phenyl or heteroaryl substituent is located at the 8-position, a substituted alkoxy moiety is located at the 2-position, and one of a group of substituents is located at the 3-position. The class of pyrido [2,3-d] pyridazine derivatives are selective ligands of the GABA A receptor, in particular those having a high affinity for the α2 and / or α3 and / or α5 subunits of the receptor. It is a ligand and is therefore effective in treating and / or preventing central nervous system pathological conditions such as anxiety, convulsions and cognitive impairment. |