http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003507064-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2000-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003507064-A |
| titleOfInvention | Transmembrane trap for isolation of membrane-bound proteins |
| abstract | (57) [Summary]nThe present invention relates to a method for identifying a transmembrane domain of a transmembrane protein. The transmembrane protein can be a group I receptor, a group II receptor, and a receptor having multiple transmembrane domains. The method involves the use of a death domain deleted protein that has been modified to replace its transmembrane domain with a candidate nucleic acid sequence. The absence of apoptosis in a host cell expressing a modified death domain deleted protein and a death domain containing protein after exposure to an apoptosis inducing ligand is a candidate nucleic acid encoding the transmembrane domain of a transmembrane receptor Indicates the presence of the sequence. Also provided are vectors and host cells that produce the modified death domain deleted proteins. The present invention further relates to a transmembrane protein containing the transmembrane domain identified by the method of the present invention and the identification of a target molecule for the transmembrane protein. The present invention also includes a method for identifying a substance that alters the interaction between a transmembrane protein identified by the method of the present invention and a target molecule. |
| priorityDate | 1999-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.