| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-121
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-346
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3183
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2000-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2003-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2003507037-A |
| titleOfInvention |
Chimeric DNA / RNA ribozyme containing propanediol |
| abstract |
(57) [Summary] Formula III 5 ′ Z-cugaugag- (Pr) n -cgaaa-X 3 ′; or Formula IV 3′X-aaagc- (Pr) n -gaguaguc-ZRZ-cugaugag- (Pr) n − cgaaa-X 3 '; DNA-RNA- (Pr) n -RNA-DNA ribozyme, where at least six 2'-deoxyribonucleotide residues base-pair with the RNA substrate at a position adjacent to the RNA cleavage site or it comprises a DNA sequence with modified 2'-deoxyribonucleotide residues; Cugaugag and cgaaa is located a catalytic RNA sequence; Pr spacer residues, -P (O) (OH) -O-CH 2 CH 2 CH 2 -O- and and; and R is -O-CH 2 -C (CH 2 OH) (CH 3) -CH 2 -O- crosslinking residues. Ribozymes can be made on any DNA synthesizer using phosphoramidite chemistry and are useful as therapeutic agents for treating viral or endogenous RNA-mediated diseases. Preferred ribozymes target sequences in the U5 region of HIV-1. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007043942-A |
| priorityDate |
1999-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |