| abstract |
(57) [Summary]nIt has been shown that administration of β-lactam compounds, including inhibitors of bacterial peptidases, has important neurotrophic effects in warm-blooded animals, demonstrated by anxiolytics and anti-aggression, and enhanced cognition Is thought to be mediated by the inhibition of enzyme activity associated with neurophilic NAALADase. β-lactam antibiotics and β-lactamase inhibitors have been shown to exhibit potent NAALADase inhibition, and these compounds, together with the blood-brain barrier, are effective neurogenic NAALADases with significant neurohealing effects. Is an inhibitor. β-Lactam compounds are useful in treating many conditions associated with glutamate abnormalities. Methods of treatment using such compounds and their pharmaceutical formulations are described. |