| abstract |
(57) [Summary]nThe present invention relates to tissues including, but not limited to, bone and cartilage grafts as carrier matrices that deliver biologically active nucleic acids to those sites to be transplanted. After transplantation, the nucleic acid bound to the graft is taken up and expressed by cells at the graft site, and produces growth factors, regenerative factors, and the like encoded by the nucleic acid. Thus, for example, where the nucleic acid encodes an osteogenic protein or the like, the rate of osteoinduction, induction of healing, and cartilage without further production, purification, isolation and delivery of protein or peptide growth factors The rate of formation or repair or repair is promoted. |