http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003503402-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4465 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 |
| filingDate | 2000-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003503402-A |
| titleOfInvention | Respiratory syncytial virus replication inhibitor |
| abstract | (57) [Summary]nThe present invention provides compounds of formula (I), their prodrugs, N-oxides, addition salts, quaternary amines, metal complexes or stereochemically isomeric forms, wherein -a 1 = A Two -A Three = A Four -Represents the formula -CH = CH-CH = CH-, -N = CH-CH = CH-, -CH = N-CH = CH-, -CH = CH-N = CH-, -CH = CH-CH = N-, wherein each hydrogen atom may be optionally substituted, and Q is represented by the formula (b-1), (b-2), (b-3), (b-4) , (B-5), (b-6), (b-7) and (b-8), wherein Alk is C 1 ~ C 6 Alkanediyl, Y 1 Is the formula -NR Two -Or -CH (NR Two R Four )-Is a divalent group; 1 Is NR Four , S, S (= O), S (= O) Two , O, CH Two , C (= O), C (= CH Two ), CH (OH), CH (CH Three ), CH (OCH Three ), CH (SCH Three ), CH (NR 5a R 5b ), CH Two -NR Four Or NR Four -CH Two And X Two Is a direct bond, CH Two , C (= O), NR Four , C 1 ~ C Four -Alkyl-NR Four , NR Four -C 1 ~ C Four -Alkyl, t is 2-5, u is 1-5, v is 2 or 3, where Alk and groups (b-3), (b-4), (b-5 ), (B-6), (b-7) and (b-8) each optionally have a hydrogen atom Three With the proviso that R Three Is hydroxy or C 1 ~ C 6 -In the case of alkyloxy, R Three Cannot replace a hydrogen atom in the α-position to the nitrogen atom, and G is a substituted C to which the substituent is attached via oxygen. 1 ~ C Ten Alkanediyl, R 1 Is an optionally substituted monocyclic heterocycle or aryl; Two Is hydrogen, formyl, C 1 ~ C 6 Alkylcarbonyl, Het carbonyl, pyrrolidinyl, piperidinyl, homopiperidinyl, C Three ~ C 7 -Cycloalkyl or N (R 6 ) Two And optionally substituted with other substituents 1 ~ C Ten -Alkyl, R Three Is hydrogen, hydroxy, C 1 ~ C 6 -Alkyl, C 1 ~ C 6 -Alkyloxy, aryl C 1 ~ C 6 -Alkyl or aryl C 1 ~ C 6 -Alkyloxy, R Four Is hydrogen, C 1 ~ C 6 -Alkyl or aryl C 1 ~ C 6 -Alkyl, R 5a , R 5b , R 5c And R 5d Is hydrogen or C 1 ~ C 6 -Alkyl or R 5a And R 5b Or R 5c And R 5d Together form the formula-(CH Two ) s -(Where s is 4 or 5) to form a divalent group; 6 Is hydrogen, C 1 ~ C Four -Alkyl, formyl, hydroxy C 1 ~ C 6 -Alkyl, C 1 ~ C 6 -Alkylcarbonyl or C 1 ~ C 6 -Alkyloxycarbonyl, aryl is optionally substituted phenyl, and Het is pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl) as a respiratory syncytial virus replication inhibitor; To their use as products and medicaments. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101123055-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4915734-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007514720-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007514717-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007514719-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016159082-A1 |
| priorityDate | 1999-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 214.