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(57) Abstract: A compound or a salt thereof or a solvate thereof represented by the formula (I), wherein, X is oxygen, sulfur or NR b, Y and Z are each independently , Nitrogen, CH, CR 1 or CR 2 , A is an unsubstituted or substituted aryl group or an unsubstituted or substituted heterocyclyl group, Ra is —C (O) NR s R t , R 1 and R 2 each independently relates to compounds that are hydrogen or a specific substituent, and the use of such compounds in the treatment and / or prevention of diseases associated with overactivity of osteoclasts in mammals. Embedded image |