| abstract |
(57) [Summary]nThe present invention relates to polymorphisms in the human HMG-CoA reductase gene and the corresponding novel allelic polypeptides encoded thereby. Specific polymorphisms in exons (15) and introns (2, 5, 15, and 18) have been described. The present invention also provides methods and materials for analyzing allelic mutations in the HMG-CoA reductase gene, as well as HMG-CoA reductase mediated diseases such as lipemic disorders and other cardiovascular diseases such as myocardial infarction and stroke. It relates to the use of HMG-CoA reductase polymorphisms in the diagnosis and treatment of diseases. |