| abstract |
The present invention relates to a compound of the general formula (I): (wherein R represents hydrogen or hydroxy; R 2 represents hydrogen or methyl; and X represents —O— or CH 2 ) and a pharmaceutically acceptable acid addition salt thereof. These compounds have good affinity for the NMDA receptor and are therefore, for example, acute forms of neurodegeneration caused by stroke or brain tumors, Alzheimer's disease, Parkinson's disease, Huntington's disease or ALS (amyotrophic lateral sclerosis) Useful for the treatment of diseases which are therapeutic indications including chronic forms of neurodegeneration such as), neurodegeneration associated with bacterial or viral infections and diseases such as schizophrenia, anxiety, depression and chronic / acute pain. It was shown that there is. |