| abstract |
(57) [Summary] [PROBLEMS] The activity of osteoclasts, a gene specifically expressed in various bone metabolic disorders such as bone destruction, which is observed in osteoporosis, rheumatoid arthritis, bone metastasis of cancer cells, etc. A novel method for testing a substance that inhibits, a preventive or therapeutic agent for bone metabolic disorder, and a substance that inhibits the activity of osteoclasts, and a preventive and / or therapeutic agent for bone metabolic disorder. The SLC4A2 is specifically expressed in osteoclasts. Use of genes and their transcripts to specifically detect osteoclasts, prevent osteoclast activity, prevent abnormal bone metabolism, and provide screening methods for therapeutic substances. |