| abstract |
(57) [Summary] [PROBLEMS] To investigate whether BACE1 acts on a substrate other than APP, establish a system capable of measuring the activity of BACE1 for cleaving a substrate other than APP, and further, to establish a system in which BACE1 is a substrate other than APP. Provided is a method for evaluating a test substance using a system capable of measuring the activity of cleaving Azheimer's disease, and for screening a safe therapeutic drug for Alzheimer's disease with few side effects. SOLUTION: A method for cleaving sialyltransferase, which comprises contacting β-secretase with sialyltransferase. |