| abstract |
(57) [Summary]nPROBLEM TO BE SOLVED: To suppress the production of interleukin-12, Effective for treating diseases involving Tarleukin 12 Providing drugs.nSOLUTION: The following formula (1)nEmbedded imagen [Wherein, R 1 Is morpholino, thiomorpholino, pipe Radinyl group, C 1-5 Substituted with an alkyl group Nil, piperidyl, pyrrolidinyl, indazolyl Or a benzimidazole group; Two Is a hydrogen atom, Hydroxyl group, C 1 -Five A hydroxyalkyl group, Boxy group, C 1-5 An alkylsulfonamide group of -OPO (O H) Two , -OPO (OCH Two Ph) Two , -OPO [OC (CH Three ) Three ] Two , -PO (OCH Two CH Three ) Two , -PO (OH) Two , -CH Two OPO [OC (CH Three ) Three ] Two , -CH Two OPO (O H) Two , -CH Two PO (OCH Two CH Three ) Two , -CH Two PO (OH) Two Or -OSO Three H And R Three Is a hydrogen atom or C 1-5 X represents an alkyl group of Is -CH Two CONH-, -CONH-, -CONHCH Two −, −CONHCH Two CH Two −, −CON (CH Three )-, -CH Two CH Two -, -CH Two O-, -CH = CH- Or -CH Two Shows NH-. 3-trifluoro represented by the formula: Methylanilide derivative or its pharmaceutically acceptable salt. |