| abstract |
(57) [Summary] [Problem] When a pyrimidine-based drug is administered for a long time, drug-resistant bacteria or drug-resistant cells appear, and there is a problem that the drug efficacy is reduced. SOLUTION: SDT1-overexpressing yeast has reduced sensitivity to pyrimidine drugs. Also, SDT1 is It was a pyrimidine-specific 5'-nucleotidase that did not exhibit hydrolytic activity on deoxyribonucleotides. Therefore, by inhibiting the activity of pyrimidine-specific 5'-nucleotidase having the same substrate specificity as SDT1, the emergence of drug resistance with respect to pyrimidine drugs can be prevented or restored. Further, by selecting a compound whose phosphorylated active metabolite does not undergo dephosphorylation by pyrimidine-specific 5'-nucleotidase having the same substrate specificity as SDT1, the emergence of drug-resistant bacteria or drug-resistant cells It is possible to obtain pyrimidine drugs with reduced frequency. |