| abstract |
(57) [Problem] To provide an antitumor agent having a novel mechanism of action different from conventional antitumor agents. SOLUTION: The general formula containing the structure of the polyether moiety of halichondrin B which is an antitumor substance derived from a marine product The compound represented by (1) was obtained. This compound is useful as an antitumor agent and as a lead compound for the development of an antitumor agent. Embedded image (Wherein, R 1 is —C (O) CH 2 P (O) (OCH 3 ) 2 , or a lower alkyl group substituted with a hydroxyl group or a protected hydroxyl group, and R 2 , R 3 , R 4 and R 5 each independently represent a hydrogen atom or a hydroxyl group protecting group.) |