http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003238415-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_129e393582e6bdf4029baf2206522f45 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-663 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2002-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00faa2b18ad144ed4ac901135724efcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0574925d903d3023163e034bbda6197f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25f2d33376a31114761cfebfa289859b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2b0b72c42259af9198c040c72314d4a |
| publicationDate | 2003-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2003238415-A |
| titleOfInvention | COX-2 inhibitor |
| abstract | (57) [Summary] [PROBLEMS] To provide a COX-2 inhibitor. SOLUTION: General formula (I) [In the formula, X is a linear or branched alkyl group having 1 to 8 carbon atoms, Y is a linear or branched alkyl group having 1 to 8 carbon atoms, a trifluoromethyl group, and a 2 to 8 carbon atom. Represents a linear or branched alkenyl group or a cycloalkyl group having 3 to 8 carbon atoms, m and n are each independently 0 or 1, ... is a single bond, and A is -S- (CH 2 ) c- (C is 0, 1, 2 or 3), B is hydrogen or a linear or branched alkyl group having 1 to 8 carbon atoms, and R 1 , R 2 , R 3 and R 4 are hydrogen A linear or branched alkyl group having 1 to 8 carbon atoms, or a pharmacologically acceptable cation, which may be the same or different and represented by a methanebisphosphonic acid derivative or a hydrate thereof. COX-2 inhibitor as a component. [Effect] The methanebisphosphonic acid derivative represented by the general formula (I) or its hydrate according to the present invention suppresses COX-2, and its pathological condition involves COX-2 in colorectal cancer, bone pain, etc. Useful for prevention and treatment of |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102276647-A |
| priorityDate | 2002-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 228.