| abstract |
PROBLEM TO BE SOLVED: To provide a DNA encoding a novel membrane-bound polypeptide (PD-1) associated with human programmed cell death. A and a method for producing the polypeptide. Kind Code: A1 Abstract: D encoding a novel membrane-bound polypeptide (PD-1) associated with human programmed cell death This is a method for producing a polypeptide using a host cell transformed with a replication and expression vector comprising NA. [Effect] Human PD-1 can be used as a therapeutic material for infectious diseases, reduction or enhancement of immune function, tumors and the like. P The DNA encoding D-1 is used as an essential template for producing PD-1, and the DNA or fragment can be used to detect the PD-1 gene. It can be used for studying the relationship with other diseases, diagnosis of diseases, and the like. In addition, PD-1 antibodies can be used as diagnostic or therapeutic agents for PD-1 related diseases. |